Summary: Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC) responses depending on the affinity of the infusion.We hypothesized that infusing monoclonal antibodies (mAbs) of escalating affinity during an immunization regimen may progressively escalate selection pressure on competing B cells, increasing their aff
Emergency situations, where mass evacuation of people is present, are serious Sound Processor problem that is difficult to resolve.Such events have become more frequent in recent years.The transportation network is a key part of the infrastructure when it comes to events with disastrous consequences, because a large population of people must be eff
Abstract Greenhouse gas Blush Palette (GHG) accounting of emissions from land use, land-use change, and forestry necessarily involves consideration of landscape fire.This is of particular importance for Australia given that natural and human fire is a common occurrence, and many ecosystems are adapted to fire, and require periodic burning for plant
Abstract.Introduction:.Randomized clinical trials (RCTs) are considered the gold standard when assessing the efficacy of interventions because randomization of treatment assignment minimizes bias in treatment effect estimates.However, if RCTs are not performed with methodological rigor, many opportunities for bias in treatment effect estimates rema
Lauren E Friedman,1 Ana Karen Manriquez Prado,2,* Gabriel Fidel Santos Malavé,2,* Juan Carlos Vélez,3 Rodrigo Winston Gillibrand Esquinazi,4 Sixto E Sanchez,5,6 Qiu-Yue Zhong,1 Bizu Gelaye,1 Michelle A Williams1 1Department of Epidemiology, Harvard T.H.Chan School of Public Health, Boston, MA, USA; 2Multidisciplinary International Res